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Dynorphin A analogs for the treatment of chronic neuropathic pain.
- Source :
-
Future medicinal chemistry [Future Med Chem] 2016; Vol. 8 (2), pp. 165-77. Date of Electronic Publication: 2016 Jan 29. - Publication Year :
- 2016
-
Abstract
- Chronic pain is one of the most ubiquitous diseases in the world, but treatment is difficult with conventional methods, due to undesirable side effects of treatments and unknown mechanisms of pathological pain states. The endogenous peptide, dynorphin A has long been established as a target for the treatment of pain. Interestingly, this unique peptide has both inhibitory (opioid in nature) and excitatory activities (nonopioid) in the CNS. Both of these effects have been found to play a role in pain and much work has been done to develop therapeutics to enhance the inhibitory effects. Here we will review the dynorphin A compounds that have been designed for the modulation of pain and will discuss where the field stands today.<br />Competing Interests: Financial & competing interests disclosure This work has been supported by U.S. Public Health Services, NIH, and NIDA P01DA006284 and R01DA013449. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
- Subjects :
- Analgesics, Non-Narcotic therapeutic use
Chronic Disease
Dynorphins chemistry
Humans
Neuralgia pathology
Neurotransmitter Agents chemistry
Neurotransmitter Agents therapeutic use
Receptors, Bradykinin chemistry
Receptors, Bradykinin metabolism
Receptors, N-Methyl-D-Aspartate antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate metabolism
Receptors, Opioid, kappa antagonists & inhibitors
Receptors, Opioid, kappa metabolism
Structure-Activity Relationship
Dynorphins therapeutic use
Neuralgia drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1756-8927
- Volume :
- 8
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Future medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 26824470
- Full Text :
- https://doi.org/10.4155/fmc.15.164