Keloids: Animal models and pathologic equivalents to study tissue fibrosis.

Authors :: Marttala J
Andrews JP
Rosenbloom J
Uitto J
Source :: Matrix biology : journal of the International Society for Matrix Biology [Matrix Biol] 2016 Apr; Vol. 51, pp. 47-54. Date of Electronic Publication: 2016 Jan 29.
Publication Year :: 2016
Abstract: Animal models are crucial for the study of fibrosis. Keloids represent a unique type of fibrotic scarring that occurs only in humans, thus presenting a challenge for those studying the pathogenesis of this disease and its therapeutic options. Here, several animal models of fibrosis currently in use are described, emphasizing recent progress and highlighting encouraging challenges.<br /> (Copyright © 2016 International Society of Matrix Biology. Published by Elsevier B.V. All rights reserved.)

Subjects :: Animals
Cicatrix, Hypertrophic physiopathology
Cicatrix, Hypertrophic therapy
Disease Models, Animal
Fibroblasts pathology
Fibrosis physiopathology
Fibrosis therapy
Humans
Keloid physiopathology
Keloid therapy
Mice
Protein Serine-Threonine Kinases genetics
Cicatrix, Hypertrophic genetics
Fibrosis genetics
Keloid genetics

Language :: English
ISSN :: 1569-1802
Volume :: 51
Database :: MEDLINE
Journal :: Matrix biology : journal of the International Society for Matrix Biology
Publication Type :: Academic Journal
Accession number :: 26827712
Full Text :: https://doi.org/10.1016/j.matbio.2016.01.014