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CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors.
- Source :
-
Nature immunology [Nat Immunol] 2016 Mar; Vol. 17 (3), pp. 304-14. Date of Electronic Publication: 2016 Feb 01. - Publication Year :
- 2016
-
Abstract
- The role of anergy, an acquired state of T cell functional unresponsiveness, in natural peripheral tolerance remains unclear. In this study, we found that anergy was selectively induced in fetal antigen-specific maternal CD4(+) T cells during pregnancy. A naturally occurring subpopulation of anergic polyclonal CD4(+) T cells, enriched for self antigen-specific T cell antigen receptors, was also present in healthy hosts. Neuropilin-1 expression in anergic conventional CD4(+) T cells was associated with hypomethylation of genes related to thymic regulatory T cells (Treg cells), and this correlated with their ability to differentiate into Foxp3(+) Treg cells that suppressed immunopathology. Thus, our data suggest that not only is anergy induction important in preventing autoimmunity but also it generates the precursors for peripheral Treg cell differentiation.
- Subjects :
- Adoptive Transfer
Animals
Arthritis, Experimental immunology
CD4-Positive T-Lymphocytes immunology
Cell Proliferation
Cytokines immunology
Enzyme-Linked Immunosorbent Assay
Female
Flow Cytometry
Forkhead Transcription Factors immunology
Genes, T-Cell Receptor alpha
Immunoblotting
Male
Mice
Mice, Knockout
Neuropilin-1 metabolism
Pregnancy
Receptors, Antigen, T-Cell immunology
Reverse Transcriptase Polymerase Chain Reaction
Self Tolerance
Thymocytes immunology
Autoimmunity immunology
Cell Differentiation immunology
Clonal Anergy immunology
Histocompatibility, Maternal-Fetal immunology
Peripheral Tolerance immunology
Precursor Cells, T-Lymphoid immunology
T-Lymphocytes, Regulatory immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1529-2916
- Volume :
- 17
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Nature immunology
- Publication Type :
- Academic Journal
- Accession number :
- 26829766
- Full Text :
- https://doi.org/10.1038/ni.3331