Back to Search
Start Over
Amyloid precursor protein and amyloid precursor-like protein 2 in cancer.
- Source :
-
Oncotarget [Oncotarget] 2016 Apr 12; Vol. 7 (15), pp. 19430-44. - Publication Year :
- 2016
-
Abstract
- Amyloid precursor protein (APP) and its family members amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are type 1 transmembrane glycoproteins that are highly conserved across species. The transcriptional regulation of APP and APLP2 is similar but not identical, and the cleavage of both proteins is regulated by phosphorylation. APP has been implicated in Alzheimer's disease causation, and in addition to its importance in neurology, APP is deregulated in cancer cells. APLP2 is likewise overexpressed in cancer cells, and APLP2 and APP are linked to increased tumor cell proliferation, migration, and invasion. In this present review, we discuss the unfolding account of these APP family members' roles in cancer progression and metastasis.
- Subjects :
- Alternative Splicing
Amino Acid Sequence
Amyloid beta-Protein Precursor chemistry
Amyloid beta-Protein Precursor genetics
Animals
Humans
Neoplasms genetics
Neoplasms pathology
Nerve Tissue Proteins chemistry
Nerve Tissue Proteins genetics
Protein Unfolding
Amyloid beta-Protein Precursor metabolism
Cell Movement
Cell Proliferation
Neoplasms metabolism
Nerve Tissue Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1949-2553
- Volume :
- 7
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Oncotarget
- Publication Type :
- Academic Journal
- Accession number :
- 26840089
- Full Text :
- https://doi.org/10.18632/oncotarget.7103