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Fibroblast Growth Factor Receptor (FGFR): A New Target for Non-small Cell Lung Cancer Therapy.
- Source :
-
Anti-cancer agents in medicinal chemistry [Anticancer Agents Med Chem] 2016; Vol. 16 (9), pp. 1142-54. - Publication Year :
- 2016
-
Abstract
- Lung cancer is still the leading cause of cancer related death worldwide. Fibroblast growth factor receptor (FGFR) is a tirosine-kinase receptor that is seen to be amplified or mutated in non-small cell lung cancer (NSCLC) and it plays a crucial role in tumour development and maintenance. The authors analyzed the state of the art of FGFR by reviewing the current literature. Fibroblast growth factor (FGF)-FGFR pathway and their aberrations are described, with the evaluation of their possible prognostic role in NSCLC and in particular in squamous cell carcinomas, in which FGFR is more often amplified. New therapeutic agents targeting FGFR signaling have been developed and are now in clinical evaluation. Dysregulation of FGF signaling in tumour cells is related to FGFR gene amplification or mutation, although it is still uncertain which of these aberrations represents a real predictor of response to specific inhibitors. However, recent evidence has questioned whether FGFR is a real target in squamous cell histology. The effectiveness of FGFR inhibitors is also still unclear since there are no clinical data on selected patients. Moreover, the management of specific side effects related to inhibition of the physiological role of FGF should be more thorough.
- Subjects :
- Animals
Antibodies, Monoclonal pharmacology
Antibodies, Monoclonal therapeutic use
Antineoplastic Agents pharmacology
Carcinoma, Non-Small-Cell Lung genetics
Carcinoma, Non-Small-Cell Lung metabolism
Carcinoma, Non-Small-Cell Lung pathology
Humans
Lung metabolism
Lung pathology
Lung Neoplasms genetics
Lung Neoplasms metabolism
Lung Neoplasms pathology
Protein Kinase Inhibitors pharmacology
Protein Kinase Inhibitors therapeutic use
Receptors, Fibroblast Growth Factor genetics
Receptors, Fibroblast Growth Factor metabolism
Signal Transduction drug effects
Small Molecule Libraries pharmacology
Small Molecule Libraries therapeutic use
Antineoplastic Agents therapeutic use
Carcinoma, Non-Small-Cell Lung drug therapy
Lung drug effects
Lung Neoplasms drug therapy
Molecular Targeted Therapy methods
Receptors, Fibroblast Growth Factor antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1875-5992
- Volume :
- 16
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Anti-cancer agents in medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 26845137
- Full Text :
- https://doi.org/10.2174/1871520616666160204112347