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Strategies in functional proteomics: Unveiling the pathways to precision oncology.
- Source :
-
Cancer letters [Cancer Lett] 2016 Nov 01; Vol. 382 (1), pp. 86-94. Date of Electronic Publication: 2016 Feb 02. - Publication Year :
- 2016
-
Abstract
- Personalised strategies in cancer care are required to overcome the therapeutic challenges posed by variability between patients and disease subsets. To this end, enhanced precision tools must be developed to describe the molecular drivers of malignant proliferation. Such tools must also identify druggable targets and biomarkers in order to provide essential information regarding drug development and therapeutic outcome. Here we discuss how proteomics-based approaches provide a set of viable methodologies capable of delivering quantitative information throughout the main stages of personalised oncology and a ratiometric platform that delivers systems-wide methods for drug evaluation.<br /> (Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Animals
Biomarkers, Tumor genetics
Computational Biology
Databases, Protein
Humans
Molecular Diagnostic Techniques
Molecular Targeted Therapy
Neoplasm Proteins genetics
Neoplasms genetics
Neoplasms pathology
Patient Selection
Predictive Value of Tests
Protein Interaction Maps
Signal Transduction drug effects
Antineoplastic Agents therapeutic use
Biomarkers, Tumor metabolism
Drug Discovery methods
Neoplasm Proteins metabolism
Neoplasms drug therapy
Neoplasms metabolism
Precision Medicine methods
Proteomics methods
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7980
- Volume :
- 382
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cancer letters
- Publication Type :
- Academic Journal
- Accession number :
- 26850375
- Full Text :
- https://doi.org/10.1016/j.canlet.2016.01.049