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Long-term heat stress induces the inflammatory response in dairy cows revealed by plasma proteome analysis.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2016 Mar 04; Vol. 471 (2), pp. 296-302. Date of Electronic Publication: 2016 Feb 04. - Publication Year :
- 2016
-
Abstract
- In this work we employed a comparative proteomic approach to evaluate seasonal heat stress and investigate proteomic alterations in plasma of dairy cows. Twelve lactating Holstein dairy cows were used and the treatments were: heat stress (n = 6) in hot summer (at the beginning of the moderate heat stress) and no heat stress (n = 6) in spring natural ambient environment, respectively. Subsequently, heat stress treatment lasted 23 days (at the end of the moderate heat stress) to investigate the alterations of plasma proteins, which might be employed as long-term moderate heat stress response in dairy cows. Changes in plasma proteins were analyzed by two-dimensional electrophoresis (2-DE) combined with mass spectrometry. Analysis of the properties of the identified proteins revealed that the alterations of plasma proteins were related to inflammation in long-term moderate heat stress. Furthermore, the increase in plasma tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) directly demonstrated that long-term moderate heat stress caused an inflammatory response in dairy cows.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Cattle Diseases blood
Cytokines blood
Female
Heat Stress Disorders blood
Heat Stress Disorders immunology
Proteome immunology
Systemic Inflammatory Response Syndrome blood
Systemic Inflammatory Response Syndrome immunology
Cattle blood
Cattle immunology
Cattle Diseases immunology
Cytokines immunology
Heat Stress Disorders veterinary
Systemic Inflammatory Response Syndrome veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 471
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 26851364
- Full Text :
- https://doi.org/10.1016/j.bbrc.2016.01.185