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Oral Supplementation with Cocoa Extract Reduces UVB-Induced Wrinkles in HairlessĀ Mouse Skin.
- Source :
-
The Journal of investigative dermatology [J Invest Dermatol] 2016 May; Vol. 136 (5), pp. 1012-1021. Date of Electronic Publication: 2016 Feb 15. - Publication Year :
- 2016
-
Abstract
- Cacao beans contain various bioactive phytochemicals that could modify the pathogeneses of certain diseases. Here, we report that oral administration of cacao powder (CP) attenuates UVB-induced skin wrinkling by the regulation of genes involved in dermal matrix production and maintenance. Transcriptome analysis revealed that 788 genes are down- or upregulated in the CP supplemented group, compared with the UVB-irradiated mouse skin controls. Among the differentially expressed genes, cathepsin G and serpin B6c play important roles in UVB-induced skin wrinkle formation. Gene regulatory network analysis also identified several candidate regulators responsible for the protective effects of CP supplementation against UVB-induced skin damage. CP also elicited antiwrinkle effects via inhibition of UVB-induced matrix metalloproteinases-1 expression in both the human skin equivalent model and human dermal fibroblasts. Inhibition of UVB-induced activator protein-1 via CP supplementation is likely to affect the expression of matrix metalloproteinases-1. CP supplementation also downregulates the expression of cathepsin G in human dermal fibroblasts. 5-(3',4'-Dihydroxyphenyl)-Ī³-valerolactone, a major in vivo metabolite of CP, showed effects similar to CP supplementation. These results suggest that cacao extract may offer a protective effect against photoaging by inhibiting the breakdown of dermal matrix, which leads to an overall reduction in wrinkle formation.<br /> (Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Administration, Oral
Analysis of Variance
Animals
Collagen metabolism
Disease Models, Animal
Female
Gene Expression Regulation
Humans
Matrix Metalloproteinase 1 genetics
Mice
Mice, Hairless
Plant Extracts pharmacology
Random Allocation
Sensitivity and Specificity
Transcription Factor AP-1 genetics
Up-Regulation
Cacao
Collagen drug effects
Dietary Supplements
Skin Aging genetics
Ultraviolet Rays adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1523-1747
- Volume :
- 136
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of investigative dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 26854493
- Full Text :
- https://doi.org/10.1016/j.jid.2015.11.032