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Impaired learning and memory in CD38 null mutant mice.
- Source :
-
Molecular brain [Mol Brain] 2016 Feb 09; Vol. 9, pp. 16. Date of Electronic Publication: 2016 Feb 09. - Publication Year :
- 2016
-
Abstract
- CD38 is an enzyme that catalyzes the formation of cyclic ADP ribose and nicotinic acid adenine dinucleotide phosphate, both of which are involved in the mobilization of Ca(2+) from intracellular stores. Recently, CD38 has been shown to regulate oxytocin release from hypothalamic neurons. Importantly, CD38 mutations are associated with autism spectrum disorders (ASD) and CD38 knockout (CD38(-/-)) mice display ASD-like behavioral phenotypes including deficient parental behavior and poor social recognition memory. Although ASD and learning deficits commonly co-occur, the role of CD38 in learning and memory has not been investigated. We report that CD38(-/-) mice show deficits in various learning and memory tasks such as the Morris water maze, contextual fear conditioning, and the object recognition test. However, either long-term potentiation or long-term depression is not impaired in the hippocampus of CD38(-/-) mice. Our results provide convincing evidence that CD38(-/-) mice show deficits in various learning and memory tasks including spatial and non-spatial memory tasks. Our data demonstrate that CD38 is critical for regulating hippocampus-dependent learning and memory without modulating synaptic plasticity.
Details
- Language :
- English
- ISSN :
- 1756-6606
- Volume :
- 9
- Database :
- MEDLINE
- Journal :
- Molecular brain
- Publication Type :
- Academic Journal
- Accession number :
- 26856703
- Full Text :
- https://doi.org/10.1186/s13041-016-0195-5