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Requirement of CD30 expression on CD4 T cells in the pathogenesis of experimental autoimmune encephalomyelitis.
- Source :
-
Journal of neuroimmunology [J Neuroimmunol] 2016 Feb 15; Vol. 291, pp. 39-45. Date of Electronic Publication: 2015 Dec 11. - Publication Year :
- 2016
-
Abstract
- CD30, a member of the tumor necrosis factor receptor superfamily, is expressed preferentially by effector or memory helper T cells. Here we show that experimental autoimmune encephalomyelitis (EAE) is ameliorated with markedly reduced induction of antigen-specific Th1 and Th17 cells in CD30 knockout mice. Passive EAE indicated that CD30 on non-hematopoietic parenchymal cell is not required and mixed bone marrow chimera experiments revealed that CD30 signaling on CD4 T cells amplified the development of antigen-specific and encephalitogenic CD4 T cells. Thus, CD30 expression on CD4 T cells is critically involved in the pathogenesis of central nervous system autoimmunity.<br /> (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
CD4-Positive T-Lymphocytes drug effects
Cytokines metabolism
Disease Models, Animal
Dose-Response Relationship, Drug
Encephalomyelitis, Autoimmune, Experimental chemically induced
Encephalomyelitis, Autoimmune, Experimental immunology
Flow Cytometry
Ki-1 Antigen genetics
Mice
Mice, Inbred C57BL
Mice, Knockout
Myelin-Oligodendrocyte Glycoprotein
Peptide Fragments
Th1 Cells immunology
Th17 Cells immunology
Thymidine metabolism
Time Factors
Tritium metabolism
CD4-Positive T-Lymphocytes metabolism
Encephalomyelitis, Autoimmune, Experimental pathology
Ki-1 Antigen deficiency
Spinal Cord pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8421
- Volume :
- 291
- Database :
- MEDLINE
- Journal :
- Journal of neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 26857493
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2015.12.005