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[Investigation of Therapeutic Efficacy of Triazavirin Against Experimental Forest-Spring Encephalitis on Albino Mice].
- Source :
-
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] [Antibiot Khimioter] 2015; Vol. 60 (7-8), pp. 11-3. - Publication Year :
- 2015
-
Abstract
- The comparative study of the therapeutic efficacy of Triazavirin against experimental Forest-Spring encephalitis on albino mice vs. the active drug Ribavirin® showed that in high doses (200-400 mg/kg) Triazavirin moderately protected the infected animals. A significant increase of the animal lifespan in the test groups (from 4.1 to 4.8 days) and a statistically (p ≤ 0.05) valid decrease of the virus accumulation in the target organ (the brain) were observed.
- Subjects :
- Animals
Brain drug effects
Brain pathology
Brain virology
Encephalitis Viruses, Tick-Borne pathogenicity
Encephalitis Viruses, Tick-Borne physiology
Encephalitis, Tick-Borne mortality
Encephalitis, Tick-Borne pathology
Encephalitis, Tick-Borne virology
Mice
Ribavirin pharmacology
Survival Analysis
Treatment Outcome
Triazoles
Viral Load drug effects
Antiviral Agents pharmacology
Azoles pharmacology
Encephalitis Viruses, Tick-Borne drug effects
Encephalitis, Tick-Borne drug therapy
Triazines pharmacology
Virus Replication drug effects
Subjects
Details
- Language :
- Russian
- ISSN :
- 0235-2990
- Volume :
- 60
- Issue :
- 7-8
- Database :
- MEDLINE
- Journal :
- Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]
- Publication Type :
- Academic Journal
- Accession number :
- 26863736