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Specific polymorphisms in the vitamin D metabolism pathway are not associated with susceptibility to Chlamydia trachomatis infection in humans.
- Source :
-
Pathogens and disease [Pathog Dis] 2016 Apr; Vol. 74 (3). Date of Electronic Publication: 2016 Feb 10. - Publication Year :
- 2016
-
Abstract
- Chlamydia trachomatis is the most common sexually transmitted bacterium worldwide. Its often asymptomatic course of infection increases chances of transmission, and increases risk of late complications. Genetic variations in the host immune system are known to impact the course of infections. Recent studies have shown a positive impact of vitamin D on the regulation of the immune system. This study assesses the impact of eight polymorphisms in five genes [VDR (rs1544410 G > A, rs2228570 C > T), CYP27B1 (rs10877012 G > T), DHCR7 (rs7944926 G > A, rs3829251 G > A), GC (rs3755967) and CYP2R1 (rs10741657 G > A, rs2060793 G > A)] on susceptibility to Chlamydia infections in humans. These polymorphisms could influence protein expression or function, and thus influence the immune system. Samples of women visiting the STD outpatient clinic in South Limburg were genotyped using the Roche Lightcycler 480. In this study, we did not observe statistically significant differences between the genotype distributions of these polymorphisms in women with or without a Chlamydia infection. This suggests that VDR, CYP27B1, DHCR7, GC and CYP2R1 do not affect the susceptibility to Chlamydia infections. However, due to its pleiotropic nature in the immune system a role for the vitamin D pathway may not be excluded from the whole clinical course of Chlamydia infections (e.g. late complications), and further research is required.<br /> (© FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- 25-Hydroxyvitamin D3 1-alpha-Hydroxylase genetics
Case-Control Studies
Cholestanetriol 26-Monooxygenase genetics
Cytochrome P450 Family 2
Female
Genotype
Humans
Oxidoreductases Acting on CH-CH Group Donors genetics
Polymorphism, Single Nucleotide genetics
Receptors, Calcitriol genetics
Chlamydia Infections pathology
Chlamydia trachomatis pathogenicity
Genetic Predisposition to Disease genetics
Vitamin D metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2049-632X
- Volume :
- 74
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Pathogens and disease
- Publication Type :
- Academic Journal
- Accession number :
- 26867646
- Full Text :
- https://doi.org/10.1093/femspd/ftw010