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Dasatinib improves insulin sensitivity and affects lipid metabolism in a patient with chronic myeloid leukaemia.
- Source :
-
BMJ case reports [BMJ Case Rep] 2016 Feb 12; Vol. 2016. Date of Electronic Publication: 2016 Feb 12. - Publication Year :
- 2016
-
Abstract
- A 65-year-old woman had been visiting our department for the treatment of type-2 diabetes mellitus since December 2012. Her glycated haemoglobin levels were well controlled (≈5.8% (40 mmol/mol)) by metformin (500 mg). In July 2014, her white cell count increased suddenly to 33 530 cells/μL and she was diagnosed with Ph+ chronic myeloid leukaemia. She was started on dasatinib (100 mg), which immediately normalised plasma levels of WCC. Dasatinib improved the glycaemic index to <6.0% and also improved plasma levels of triglycerides (TGs) and high-density lipoprotein-cholesterol (HDL-c). Levels of low-density lipoprotein-cholesterol were increased but remained within the normal range. The TG:HDL-c ratio and Quantitative Insulin Sensitivity Check Index rapidly improved. Followed by an improvement in insulin sensitivity, plasma levels of adiponectin and leptin were increased. This case study suggests that dasatinib might have positive as well as negative effects on the metabolism of glucose and lipids.<br /> (2016 BMJ Publishing Group Ltd.)
- Subjects :
- Aged
Antineoplastic Agents pharmacology
Blood Glucose analysis
Dasatinib pharmacology
Diabetes Mellitus, Type 2 drug therapy
Female
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy
Antineoplastic Agents therapeutic use
Dasatinib therapeutic use
Diabetes Mellitus, Type 2 complications
Insulin Resistance
Leukemia, Myelogenous, Chronic, BCR-ABL Positive complications
Lipid Metabolism drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1757-790X
- Volume :
- 2016
- Database :
- MEDLINE
- Journal :
- BMJ case reports
- Publication Type :
- Academic Journal
- Accession number :
- 26873919
- Full Text :
- https://doi.org/10.1136/bcr-2015-214284