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Dendronized Anionic Gold Nanoparticles: Synthesis, Characterization, and Antiviral Activity.
- Source :
-
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2016 Feb 24; Vol. 22 (9), pp. 2987-99. Date of Electronic Publication: 2016 Jan 27. - Publication Year :
- 2016
-
Abstract
- Anionic carbosilane dendrons decorated with sulfonate functions and one thiol moiety at the focal point have been used to synthesize water-soluble gold nanoparticles (AuNPs) through the direct reaction of dendrons, gold precursor, and reducing agent in water, and also through a place-exchange reaction. These nanoparticles have been characterized by NMR spectroscopy, TEM, thermogravimetric analysis, X-ray photoelectron spectroscopy (XPS), UV/Vis spectroscopy, elemental analysis, and zeta-potential measurements. The interacting ability of the anionic sulfonate functions was investigated by EPR spectroscopy with copper(II) as a probe. Different structures and conformations of the AuNPs modulate the availability of sulfonate and thiol groups for complexation by copper(II). Toxicity assays of AuNPs showed that those produced through direct reaction were less toxic than those obtained by ligand exchange. Inhibition of HIV-1 infection was higher in the case of dendronized AuNPs than in dendrons.<br /> (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Antiviral Agents chemistry
Electron Spin Resonance Spectroscopy
Photoelectron Spectroscopy
Spectrophotometry, Ultraviolet
Anions chemistry
Antiviral Agents chemical synthesis
Antiviral Agents pharmacology
Dendrimers chemistry
Gold chemistry
HIV-1 chemistry
Metal Nanoparticles chemistry
Silanes chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1521-3765
- Volume :
- 22
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Chemistry (Weinheim an der Bergstrasse, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 26875938
- Full Text :
- https://doi.org/10.1002/chem.201504262