Novel Feline Leukemia Virus Interference Group Based on the env Gene.

Authors :: Miyake A
Watanabe S
Hiratsuka T
Ito J
Ngo MH
Makundi I
Kawasaki J
Endo Y
Tsujimoto H
Nishigaki K
Source :: Journal of virology [J Virol] 2016 Apr 14; Vol. 90 (9), pp. 4832-4837. Date of Electronic Publication: 2016 Apr 14 (Print Publication: 2016).
Publication Year :: 2016
Abstract: Feline leukemia virus (FeLV) subgroups have emerged in infected cats via the mutation or recombination of the env gene of subgroup A FeLV (FeLV-A), the primary virus. We report the isolation and characterization of a novel env gene, TG35-2, and report that the TG35-2 pseudotype can be categorized as a novel FeLV subgroup. The TG35-2 envelope protein displays strong sequence identity to FeLV-A Env, suggesting that selection pressure in cats causes novel FeLV subgroups to emerge.<br /> (Copyright © 2016, American Society for Microbiology. All Rights Reserved.)