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Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β.

Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β.

Authors :
Mohammed J
Beura LK
Bobr A
Astry B
Chicoine B
Kashem SW
Welty NE
Igyártó BZ
Wijeyesinghe S
Thompson EA
Matte C
Bartholin L
Kaplan A
Sheppard D
Bridges AG
Shlomchik WD
Masopust D
Kaplan DH
Source :
Nature immunology [Nat Immunol] 2016 Apr; Vol. 17 (4), pp. 414-21. Date of Electronic Publication: 2016 Feb 22.
Publication Year :
2016

Abstract

Cells of the immune system that reside in barrier epithelia provide a first line of defense against pathogens. Langerhans cells (LCs) and CD8(+) tissue-resident memory T cells (TRM cells) require active transforming growth factor-β1 (TGF-β) for epidermal residence. Here we found that integrins αvβ6 and αvβ8 were expressed in non-overlapping patterns by keratinocytes (KCs) and maintained the epidermal residence of LCs and TRM cells by activating latent TGF-β. Similarly, the residence of dendritic cells and TRM cells in the small intestine epithelium also required αvβ6. Treatment of the skin with ultraviolet irradiation decreased integrin expression on KCs and reduced the availability of active TGF-β, which resulted in LC migration. Our data demonstrated that regulated activation of TGF-β by stromal cells was able to directly control epithelial residence of cells of the immune system through a novel mechanism of intercellular communication.<br />Competing Interests: The authors declare no competing financial interests.

Details

Language :
English
ISSN :
1529-2916
Volume :
17
Issue :
4
Database :
MEDLINE
Journal :
Nature immunology
Publication Type :
Academic Journal
Accession number :
26901152
Full Text :
https://doi.org/10.1038/ni.3396