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Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β.
Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β.
- Source :
-
Nature immunology [Nat Immunol] 2016 Apr; Vol. 17 (4), pp. 414-21. Date of Electronic Publication: 2016 Feb 22. - Publication Year :
- 2016
-
Abstract
- Cells of the immune system that reside in barrier epithelia provide a first line of defense against pathogens. Langerhans cells (LCs) and CD8(+) tissue-resident memory T cells (TRM cells) require active transforming growth factor-β1 (TGF-β) for epidermal residence. Here we found that integrins αvβ6 and αvβ8 were expressed in non-overlapping patterns by keratinocytes (KCs) and maintained the epidermal residence of LCs and TRM cells by activating latent TGF-β. Similarly, the residence of dendritic cells and TRM cells in the small intestine epithelium also required αvβ6. Treatment of the skin with ultraviolet irradiation decreased integrin expression on KCs and reduced the availability of active TGF-β, which resulted in LC migration. Our data demonstrated that regulated activation of TGF-β by stromal cells was able to directly control epithelial residence of cells of the immune system through a novel mechanism of intercellular communication.<br />Competing Interests: The authors declare no competing financial interests.
- Subjects :
- Animals
Antigens, Neoplasm immunology
CD8-Positive T-Lymphocytes cytology
Cell Movement
Epidermal Cells
Flow Cytometry
Fluorescent Antibody Technique
Humans
Immunity, Mucosal
Integrins immunology
Intestinal Mucosa cytology
Intestine, Small cytology
Intestine, Small immunology
Langerhans Cells cytology
Mice
Mice, Knockout
Mink
Polymerase Chain Reaction
Stromal Cells
T-Lymphocyte Subsets cytology
T-Lymphocyte Subsets immunology
T-Lymphocytes cytology
T-Lymphocytes immunology
Transforming Growth Factor beta1 immunology
CD8-Positive T-Lymphocytes immunology
Epidermis immunology
Intestinal Mucosa immunology
Keratinocytes immunology
Langerhans Cells immunology
Transforming Growth Factor beta immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1529-2916
- Volume :
- 17
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Nature immunology
- Publication Type :
- Academic Journal
- Accession number :
- 26901152
- Full Text :
- https://doi.org/10.1038/ni.3396