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Brief Report: HIV Infection Is Associated With Worse Bone Material Properties, Independently of Bone Mineral Density.
- Source :
-
Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2016 Jul 01; Vol. 72 (3), pp. 314-8. - Publication Year :
- 2016
-
Abstract
- Low bone mineral density (BMD) in HIV-infected individuals has been documented in an increasing number of studies. However, it is not clear whether it is the infection itself or the treatment that causes bone impairment. Microindentation measures bone material strength (Bone Material Strength index) directly. We recruited 85 patients, 50 infected with HIV and 35 controls. Median Bone Material Strength index was 84.5 (interquartile range 83-87) in HIV-infected patients and 90 (88.5-93) in controls (P < 0.001). No significant differences in BMD between cases and controls at any of the sites examined (total hip, femoral neck, and lumbar spine). HIV infection is associated with bone damage, independently of BMD.
- Subjects :
- Absorptiometry, Photon
Adult
Anti-HIV Agents adverse effects
Bone Density
Cross-Sectional Studies
Female
Femur Neck virology
HIV Infections pathology
HIV Infections virology
Humans
Lumbar Vertebrae virology
Male
Middle Aged
Osteoporosis virology
Risk Assessment
Spain
Anti-HIV Agents administration & dosage
Femur Neck pathology
HIV Infections complications
Lumbar Vertebrae pathology
Osteoporosis pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1944-7884
- Volume :
- 72
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of acquired immune deficiency syndromes (1999)
- Publication Type :
- Academic Journal
- Accession number :
- 26910501
- Full Text :
- https://doi.org/10.1097/QAI.0000000000000965