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Changes in synovial fluid biomarkers and clinical efficacy of intra-articular injections of hyaluronic acid for patients with knee osteoarthritis.
- Source :
-
Journal of experimental orthopaedics [J Exp Orthop] 2014 Dec; Vol. 1 (1), pp. 16. Date of Electronic Publication: 2014 Dec 20. - Publication Year :
- 2014
-
Abstract
- Background: The changes in synovial fluid biomarkers after intra-articular injection of hyarulonic acid (IA HA) remain controversial. We investigate the changes in the properties of synovial fluid (SF) and clinical symptoms before the first and fifth IA HA.<br />Methods: A total of 73 patients (73 knees) with symptomatic knee osteoarthritis were treated with five weekly intra-articular injections of HA and 55 patients (55 knees) were analyzed. The SF total volume, viscosity, and levels of HA, chondroitin 4-sulfate (C4S), chondroitin 6-sulfate (C6S), keratin sulfate, and interleukin (IL)-6 were measured before the first and fifth injections. Clinical evaluations were performed using the American Knee Society score for physician-based outcome measurements and Knee injury and Osteoarthritis Outcome Score for patient-based outcome measurements before the first and fifth injections.<br />Results: The SF viscosity and levels of HA were significantly increased, and the total SF volume and levels of chondroitin 4-sulfate, chondroitin 6-sulfate, and interleukin-6 were significantly decreased. The physician-based and patient-based outcome scores were improved.<br />Conclusions: Our findings speculate that HA injections significantly modulate levels of intra articular biomarkers which may indicate beneficial effect for articular cartilage and synovium membrane.
Details
- Language :
- English
- ISSN :
- 2197-1153
- Volume :
- 1
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of experimental orthopaedics
- Publication Type :
- Academic Journal
- Accession number :
- 26914761
- Full Text :
- https://doi.org/10.1186/s40634-014-0016-7