Back to Search
Start Over
Specificity of mannan antigen and anti-mannan antibody screening in patients with haematological malignancies at risk for fungal infection.
- Source :
-
Mycoses [Mycoses] 2016 Jun; Vol. 59 (6), pp. 374-8. Date of Electronic Publication: 2016 Feb 25. - Publication Year :
- 2016
-
Abstract
- Combination of mannan antigen and anti-mannan antibody (Mn/A-Mn) testing has been reported a useful and specific strategy for diagnosis of invasive Candida infections (ICIs). We evaluated Mn/A-Mn as a screening tool in patients with haematological malignancies. This clinical prospective study was performed at the Division of Hematology, Medical University Graz, Austria between July and December 2012. Patients at risk for fungal infection were included into the study and twice weekly screened by Mn/A-Mn testing, yielding 650 samples. Of overall 67 patients 66 had no evidence for ICI. From those, 153/640 serum samples (23.9%) were positive for mannan Ab, and nine (1.4%) for Ag. Most false positive Ab results were observed among 375 samples from patients without haematopoietic stem cell transplantation (34.9% resulted positive). Combined specificity of Mn/A-Mn was 74.8%. Of 10 samples obtained in the single patient with candidemia, five were positive for mannan Ag (from the day of diagnosis up to 40 days after detection of candidemia) and none for Ab. In conclusion, mannan Ab screening yielded a high number of false positive results. While mannan Ag was found to be highly specific and may have potential for diagnostic driven testing, mannan Ab testing cannot be recommended based on our study results.<br /> (© 2016 Blackwell Verlag GmbH.)
- Subjects :
- Adult
Aged
Austria
Candida immunology
Candidemia diagnosis
Candidemia drug therapy
Candidemia immunology
Candidemia microbiology
Candidiasis, Invasive drug therapy
Candidiasis, Invasive immunology
Candidiasis, Invasive microbiology
False Positive Reactions
Female
Hematologic Neoplasms microbiology
Humans
Male
Middle Aged
Prospective Studies
Risk Factors
Sensitivity and Specificity
Young Adult
Antibodies, Fungal blood
Antigens, Fungal blood
Candidiasis, Invasive diagnosis
Hematologic Neoplasms complications
Mannans blood
Mannans immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1439-0507
- Volume :
- 59
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Mycoses
- Publication Type :
- Academic Journal
- Accession number :
- 26916753
- Full Text :
- https://doi.org/10.1111/myc.12482