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HbA1c and Gestational Weight Gain Are Factors that Influence Neonatal Outcome in Mothers with Gestational Diabetes.
- Source :
-
Journal of women's health (2002) [J Womens Health (Larchmt)] 2016 Jun; Vol. 25 (6), pp. 579-85. Date of Electronic Publication: 2016 Feb 26. - Publication Year :
- 2016
-
Abstract
- Background: Maternal glucose and weight gain are related to neonatal outcome in women with gestational diabetes mellitus (GDM). The aim of this study was to explore the influence of average third-trimester HbA1c and excess gestational weight gain on GDM neonatal complications.<br />Materials and Methods: This observational study included 2037 Spanish singleton pregnant women with GDM followed in our Diabetes and Pregnancy Unit. The maternal HbA1c level was measured monthly from GDM diagnosis to delivery. Women were compared by average HbA1c level and weight gain categorized into ≤ or > the current Institute of Medicine (IOM) recommendations for body mass index. The differential effects of these factors on large-for-gestational-age birth weight and a composite of neonatal complications were assessed.<br />Results: Women with an average third-trimester HbA1c ≥5.0% (n = 1319) gave birth to 7.3% versus 3.8% (p = 0.005) of large-for-gestational-age neonates and 22.0% versus 16.0% (p = 0.006) of neonates with complications. Women with excess gestational weight gain (n = 299) delivered 12.5% versus 5.2% (p < 0.001) of large-for-gestational-age neonates and 24.7% versus 19.0% (p = 0.022) of neonates with complications. In an adjusted multiple logistic regression analysis among mothers exposed to the respective risk factors, ∼47% and 52% of large-for-gestational-age neonates and 32% and 37% of neonatal complications were potentially preventable by attaining an average third-trimester HbA1c level <5.0% and optimizing gestational weight gain.<br />Conclusions: Average third-trimester HbA1c level ≥5% and gestational weight gain above the IOM recommendation are relevant risk factors for neonatal complications in mothers with gestational diabetes.
- Subjects :
- Adult
Birth Weight
Blood Glucose metabolism
Body Mass Index
Diabetes Mellitus, Type 2 epidemiology
Diabetes, Gestational ethnology
Female
Fetal Macrosomia ethnology
Gestational Age
Hispanic or Latino statistics & numerical data
Humans
Infant, Newborn
Obesity complications
Postprandial Period
Pregnancy
Pregnancy Complications epidemiology
Pregnancy Trimester, Third
Pregnancy in Diabetics blood
Pregnancy in Diabetics ethnology
Retrospective Studies
Risk Factors
Socioeconomic Factors
United States
Diabetes, Gestational blood
Fetal Macrosomia etiology
Glycated Hemoglobin metabolism
Mothers
Obesity epidemiology
Weight Gain
Subjects
Details
- Language :
- English
- ISSN :
- 1931-843X
- Volume :
- 25
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of women's health (2002)
- Publication Type :
- Academic Journal
- Accession number :
- 26918922
- Full Text :
- https://doi.org/10.1089/jwh.2015.5432