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Mirtazapine prevents induction and expression of cocaine-induced behavioral sensitization in rats.
Mirtazapine prevents induction and expression of cocaine-induced behavioral sensitization in rats.
- Source :
-
Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2016 Jul 04; Vol. 68, pp. 15-24. Date of Electronic Publication: 2016 Feb 26. - Publication Year :
- 2016
-
Abstract
- Cocaine abuse is a major health problem worldwide. Treatment based on both 5-HT2A/C and 5-HT3 receptor antagonists attenuate not only the effects of cocaine abuse but also the incentive/motivational effect related to cocaine-paired cues. Mirtazapine, an antagonist of postsynaptic α2-adrenergic, 5-HT2A/C and 5HT3 receptors and inverse agonist of the 5-HT2C receptor, has been shown to effectively modify, at the preclinical and clinical levels, various behavioral alterations induced by drugs abuse. Therefore, it is important to assess whether chronic dosing of mirtazapine alters locomotor effects of cocaine as well as induction and expression of cocaine sensitization. Our results reveal that a daily mirtazapine regimen administered for 30days effectively induces a significant attenuation of cocaine-dependent locomotor activity and as well as the induction and expression of behavioral sensitization. These results suggest that mirtazapine may be used as a potentially effective therapy to attenuate induction and expression of cocaine-induced locomotor sensitization.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Subjects :
- Adrenergic alpha-Antagonists administration & dosage
Animals
Male
Mianserin administration & dosage
Mianserin pharmacology
Mirtazapine
Rats
Rats, Wistar
Serotonin Agents administration & dosage
Adrenergic alpha-Antagonists pharmacology
Behavior, Animal drug effects
Central Nervous System Sensitization drug effects
Cocaine adverse effects
Dopamine Uptake Inhibitors adverse effects
Mianserin analogs & derivatives
Motor Activity drug effects
Serotonin Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1878-4216
- Volume :
- 68
- Database :
- MEDLINE
- Journal :
- Progress in neuro-psychopharmacology & biological psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 26922897
- Full Text :
- https://doi.org/10.1016/j.pnpbp.2016.02.010