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The molecular mechanics of mixed lineage leukemia.
- Source :
-
Oncogene [Oncogene] 2016 Oct 06; Vol. 35 (40), pp. 5215-5223. Date of Electronic Publication: 2016 Feb 29. - Publication Year :
- 2016
-
Abstract
- Mixed lineage leukemia caused by MLL fusion proteins is still a mostly incurable disease. Research on novel treatment strategies has gained momentum in the last years with the elucidation of the molecular mechanisms underlying the transforming potential of these powerful oncoproteins. This review summarizes the recent developments in this area including new attempts to treat MLL in a rational way by exploiting the biochemical vulnerabilities of the leukemogenic process.
- Subjects :
- Animals
Gene Expression Regulation, Neoplastic drug effects
Humans
Leukemia genetics
Leukemia pathology
Methyltransferases antagonists & inhibitors
Mice
Molecular Targeted Therapy
Neoplasm Proteins biosynthesis
Oncogene Proteins, Fusion antagonists & inhibitors
Small Molecule Libraries therapeutic use
Histone-Lysine N-Methyltransferase genetics
Leukemia therapy
Methyltransferases genetics
Myeloid-Lymphoid Leukemia Protein genetics
Oncogene Proteins, Fusion genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1476-5594
- Volume :
- 35
- Issue :
- 40
- Database :
- MEDLINE
- Journal :
- Oncogene
- Publication Type :
- Academic Journal
- Accession number :
- 26923329
- Full Text :
- https://doi.org/10.1038/onc.2016.30