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A high-fat diet decreases GABA concentration in the frontal cortex and hippocampus of rats.
- Source :
-
Biological research [Biol Res] 2016 Feb 29; Vol. 49, pp. 15. Date of Electronic Publication: 2016 Feb 29. - Publication Year :
- 2016
-
Abstract
- Background: It has been proposed that the γ-aminobutyric acid (GABA) plays a key role in the regulation of food intake and body weight by controlling the excitability, plasticity and the synchronization of neuronal activity in the frontal cortex (FC). It has been also proposed that the high-fat diet (HFD) could disturb the metabolism of glutamate and consequently the GABA levels, but the mechanism is not yet clearly understood. Therefore, the aim of this study was to investigate the effect of a HFD on the GABA levels in the FC and hippocampus of rats.<br />Results: The HFD significantly increased weight gain and blood glucose levels, whereas decreased the GABA levels in the FC and hippocampus compared with standard diet-fed rats.<br />Conclusions: HFD decreases GABA levels in the FC and hippocampus of rat, which likely disrupts the GABAergic inhibitory processes, underlying feeding behavior.
- Subjects :
- Animals
Blood Glucose analysis
Body Weight
Feeding Behavior
Frontal Lobe metabolism
Hippocampus metabolism
Male
Obesity metabolism
Rats, Wistar
Reference Values
Weight Gain
gamma-Aminobutyric Acid metabolism
Diet, High-Fat
Frontal Lobe chemistry
Hippocampus chemistry
gamma-Aminobutyric Acid analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0717-6287
- Volume :
- 49
- Database :
- MEDLINE
- Journal :
- Biological research
- Publication Type :
- Academic Journal
- Accession number :
- 26927389
- Full Text :
- https://doi.org/10.1186/s40659-016-0075-6