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[Swiss simvastatin multicenter study: 1. Efficacy of 10 mg simvastatin daily in patients with primary hypercholesterolemia].
- Source :
-
Schweizerische medizinische Wochenschrift [Schweiz Med Wochenschr] 1989 Dec 02; Vol. 119 (48), pp. 1719-23. - Publication Year :
- 1989
-
Abstract
- In a Swiss multicenter study with determination of lipid and lipoprotein parameters in a central laboratory, the efficacy of simvastatin, MSD, was evaluated in patients with primary hypercholesterolemia. Lipid and lipoprotein values were determined in 109 patients before and after 6 weeks' therapy with 10 mg simvastatin per day. A significant decrease in total cholesterol, LDL-cholesterol and apo B, of 21.1, 25.8 and 24.1% respectively, was observed. No influence of simvastatin on apo A-II was found, but HDL-cholesterol and apo A-I were slightly increased (+6.1 and 4.4% respectively). The data show that HMG-CoA reductase inhibitors constitute a new class of effective drugs for the treatment of hypercholesterolemia.
- Subjects :
- Adult
Aged
Apolipoproteins blood
Cholesterol blood
Humans
Hypercholesterolemia blood
Lipids blood
Lipoproteins blood
Lovastatin administration & dosage
Lovastatin therapeutic use
Middle Aged
Multicenter Studies as Topic
Simvastatin
Single-Blind Method
Switzerland
Anticholesteremic Agents therapeutic use
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hypercholesterolemia drug therapy
Lovastatin analogs & derivatives
Subjects
Details
- Language :
- German
- ISSN :
- 0036-7672
- Volume :
- 119
- Issue :
- 48
- Database :
- MEDLINE
- Journal :
- Schweizerische medizinische Wochenschrift
- Publication Type :
- Academic Journal
- Accession number :
- 2694363