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Development and assessment of countermeasure formulations for treatment of lung injury induced by chlorine inhalation.
- Source :
-
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2016 May 01; Vol. 298, pp. 9-18. Date of Electronic Publication: 2016 Mar 04. - Publication Year :
- 2016
-
Abstract
- Chlorine is a commonly used, reactive compound to which humans can be exposed via accidental or intentional release resulting in acute lung injury. Formulations of rolipram (a phosphodiesterase inhibitor), triptolide (a natural plant product with anti-inflammatory properties), and budesonide (a corticosteroid), either neat or in conjunction with poly(lactic:glycolic acid) (PLGA), were developed for treatment of chlorine-induced acute lung injury by intramuscular injection. Formulations were produced by spray-drying, which generated generally spherical microparticles that were suitable for intramuscular injection. Multiple parameters were varied to produce formulations with a wide range of in vitro release kinetics. Testing of selected formulations in chlorine-exposed mice demonstrated efficacy against key aspects of acute lung injury. The results show the feasibility of developing microencapsulated formulations that could be used to treat chlorine-induced acute lung injury by intramuscular injection, which represents a preferred route of administration in a mass casualty situation.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Acute Lung Injury chemically induced
Animals
Budesonide administration & dosage
Budesonide blood
Chemistry, Pharmaceutical
Diterpenes administration & dosage
Diterpenes blood
Drug Carriers chemistry
Drug Liberation
Epoxy Compounds administration & dosage
Epoxy Compounds blood
Epoxy Compounds therapeutic use
Injections, Intramuscular
Male
Mice, Inbred Strains
Microscopy, Electron, Scanning
Phenanthrenes administration & dosage
Phenanthrenes blood
Rolipram administration & dosage
Rolipram blood
Surface Properties
Acute Lung Injury prevention & control
Budesonide therapeutic use
Chlorine toxicity
Diterpenes therapeutic use
Drug Discovery methods
Inhalation Exposure adverse effects
Phenanthrenes therapeutic use
Rolipram therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0333
- Volume :
- 298
- Database :
- MEDLINE
- Journal :
- Toxicology and applied pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 26952014
- Full Text :
- https://doi.org/10.1016/j.taap.2016.03.001