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Hereditary cancer syndromes as model systems for chemopreventive agent development.

Authors :
Walcott FL
Patel J
Lubet R
Rodriguez L
Calzone KA
Source :
Seminars in oncology [Semin Oncol] 2016 Feb; Vol. 43 (1), pp. 134-145. Date of Electronic Publication: 2015 Sep 07.
Publication Year :
2016

Abstract

Research in chemoprevention has undergone a shift in emphasis for pragmatic reasons from large, phase III randomized studies to earlier phase studies focused on safety, mechanisms, and utilization of surrogate endpoints such as biomarkers instead of cancer incidence. This transition permits trials to be conducted in smaller populations and at substantially reduced costs while still yielding valuable information. This article will summarize some of the current chemoprevention challenges and the justification for the use of animal models to facilitate identification and testing of chemopreventive agents as illustrated though four inherited cancer syndromes. Preclinical models of inherited cancer syndromes serve as prototypical systems in which chemopreventive agents can be developed for ultimate application to both the sporadic and inherited cancer settings.<br /> (Published by Elsevier Inc.)

Details

Language :
English
ISSN :
1532-8708
Volume :
43
Issue :
1
Database :
MEDLINE
Journal :
Seminars in oncology
Publication Type :
Academic Journal
Accession number :
26970132
Full Text :
https://doi.org/10.1053/j.seminoncol.2015.09.015