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Hereditary cancer syndromes as model systems for chemopreventive agent development.
- Source :
-
Seminars in oncology [Semin Oncol] 2016 Feb; Vol. 43 (1), pp. 134-145. Date of Electronic Publication: 2015 Sep 07. - Publication Year :
- 2016
-
Abstract
- Research in chemoprevention has undergone a shift in emphasis for pragmatic reasons from large, phase III randomized studies to earlier phase studies focused on safety, mechanisms, and utilization of surrogate endpoints such as biomarkers instead of cancer incidence. This transition permits trials to be conducted in smaller populations and at substantially reduced costs while still yielding valuable information. This article will summarize some of the current chemoprevention challenges and the justification for the use of animal models to facilitate identification and testing of chemopreventive agents as illustrated though four inherited cancer syndromes. Preclinical models of inherited cancer syndromes serve as prototypical systems in which chemopreventive agents can be developed for ultimate application to both the sporadic and inherited cancer settings.<br /> (Published by Elsevier Inc.)
- Subjects :
- Adaptor Proteins, Signal Transducing genetics
Adenomatous Polyposis Coli genetics
Adenosine Triphosphatases metabolism
Animals
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Anticarcinogenic Agents pharmacology
Aspirin therapeutic use
Chemoprevention
Colorectal Neoplasms, Hereditary Nonpolyposis genetics
Cyclooxygenase 2 Inhibitors therapeutic use
DNA Repair Enzymes metabolism
DNA-Binding Proteins genetics
DNA-Binding Proteins metabolism
Drug Discovery
Female
Genes, APC
Genes, BRCA1
Genes, BRCA2
Hereditary Breast and Ovarian Cancer Syndrome genetics
Humans
Hypoglycemic Agents therapeutic use
Li-Fraumeni Syndrome genetics
Metformin therapeutic use
Mismatch Repair Endonuclease PMS2
MutL Protein Homolog 1
MutS Homolog 2 Protein genetics
Mutation
Nuclear Proteins genetics
Penetrance
Poly(ADP-ribose) Polymerase Inhibitors therapeutic use
Selective Estrogen Receptor Modulators therapeutic use
Tumor Suppressor Protein p53 genetics
Tumor Suppressor Protein p53 metabolism
Adenomatous Polyposis Coli prevention & control
Anticarcinogenic Agents therapeutic use
Colorectal Neoplasms, Hereditary Nonpolyposis prevention & control
Disease Models, Animal
Hereditary Breast and Ovarian Cancer Syndrome prevention & control
Li-Fraumeni Syndrome prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8708
- Volume :
- 43
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Seminars in oncology
- Publication Type :
- Academic Journal
- Accession number :
- 26970132
- Full Text :
- https://doi.org/10.1053/j.seminoncol.2015.09.015