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Health-related physical fitness in patients with multiple myeloma or lymphoma recently treated with autologous stem cell transplantation.
- Source :
-
Journal of science and medicine in sport [J Sci Med Sport] 2017 Feb; Vol. 20 (2), pp. 116-122. Date of Electronic Publication: 2016 Feb 08. - Publication Year :
- 2017
-
Abstract
- Objectives: We aimed to examine health-related physical fitness and its demographic and clinical correlates in patients recently treated with autologous stem cell transplantation.<br />Design: Cross-sectional study.<br />Methods: In 109 patients (multiple myeloma: n=58, lymphoma: n=51, median age: 55, range: 19-67 years) maximal exercise testing was conducted to assess cardiorespiratory fitness (VO <subscript>2peak</subscript> ). Upper and lower extremity muscle strength were assessed with hand grip- and fixed dynamometry and body composition with whole body DXA scans. In addition, we assessed the patients' demographic and clinical characteristics and examined whether they were associated with health-related physical fitness.<br />Results: VO <subscript>2peak</subscript> was 21.7 (5.5) mL/min/kg, 26% below reference values. Muscle strength was also reduced when compared with reference values (upper extremity: 90%, lower extremity: 80%) and 73% of our population was classified as overweight or obese. Being female and being older were significantly associated with a lower cardiorespiratory fitness (gender: β=-2.7, 95%CI=-4.6;-0.7mL/min/kg; age: β=-0.2, 95%CI=-0.3;-0.1mL/min/kg), upper (gender: β=-17.7, 95%CI=-20.1;-15.3kg; age: β=-0.2, 95%CI=-0.3;-0.1kg) and lower (gender: β=-58.3, 95%CI=-73.5;- 43.0Nm; age: β=-1.7, 95%CI=-2.4;-1.1Nm) extremity muscle strength. Patients who were non-smoking (β=-5.3, 95%CI=-8.7;-1.9), women (β=7.2, 95%CI=4.8;9.6) and diagnosed with multiple myeloma (β=4.6, 95%CI=2.2;6.9) had a higher percentage body fat.<br />Conclusions: The physical fitness deficits in this population indicate the need for targeted interventions.<br />Trial Registration: Netherlands Trial Register - NTR2341.<br /> (Copyright © 2016 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Age Factors
Aged
Body Mass Index
Cross-Sectional Studies
Exercise Test methods
Female
Humans
Male
Middle Aged
Regression Analysis
Sex Factors
Surveys and Questionnaires
Transplantation, Autologous adverse effects
Lymphoma surgery
Multiple Myeloma surgery
Muscle Strength physiology
Physical Fitness physiology
Stem Cell Transplantation adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1861
- Volume :
- 20
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of science and medicine in sport
- Publication Type :
- Academic Journal
- Accession number :
- 26971299
- Full Text :
- https://doi.org/10.1016/j.jsams.2016.01.006