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In vivo risk evaluation of carbon-coated iron carbide nanoparticles based on short- and long-term exposure scenarios.
- Source :
-
Nanomedicine (London, England) [Nanomedicine (Lond)] 2016 Apr; Vol. 11 (7), pp. 783-96. Date of Electronic Publication: 2016 Mar 16. - Publication Year :
- 2016
-
Abstract
- Background: While carbon-encapsulated iron carbide nanoparticles exhibit strong magnetic properties appealing for biomedical applications, potential side effects of such materials remain comparatively poorly understood. Here, we assess the effects of iron-based nanoparticles in an in vivo long-term study in mice with observation windows between 1 week and 1 year.<br />Materials & Methods: Functionalized (PEG or IgG) carbon-encapsulated platinum-spiked iron carbide nanoparticles were injected intravenously in mice (single or repeated dose administration).<br />Results: One week after administration, magnetic nanoparticles were predominantly localized in organs of the reticuloendothelial system, particularly the lung and liver. After 1 year, particles were still present in these organs, however, without any evident tissue alterations, such as inflammation, fibrosis, necrosis or carcinogenesis. Importantly, reticuloendothelial system organs presented with normal function.<br />Conclusion: This long-term exposure study shows high in vivo compatibility of intravenously applied carbon-encapsulated iron nanoparticles suggesting continuing investigations on such materials for biomedical applications.
- Subjects :
- Animals
Carbon administration & dosage
Carbon chemistry
Carbon pharmacokinetics
Carbon Compounds, Inorganic administration & dosage
Carbon Compounds, Inorganic chemistry
Carbon Compounds, Inorganic pharmacokinetics
Coated Materials, Biocompatible administration & dosage
Coated Materials, Biocompatible chemistry
Drug Carriers administration & dosage
Drug Carriers chemistry
Drug Carriers pharmacokinetics
Female
Iron Compounds administration & dosage
Iron Compounds chemistry
Iron Compounds pharmacokinetics
Liver drug effects
Liver metabolism
Liver ultrastructure
Lung drug effects
Lung metabolism
Lung ultrastructure
Magnets adverse effects
Magnets chemistry
Male
Mice
Mice, Inbred C57BL
Nanoparticles administration & dosage
Nanoparticles analysis
Nanoparticles chemistry
Carbon adverse effects
Carbon Compounds, Inorganic adverse effects
Coated Materials, Biocompatible adverse effects
Drug Carriers adverse effects
Iron Compounds adverse effects
Nanoparticles adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1748-6963
- Volume :
- 11
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Nanomedicine (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 26979124
- Full Text :
- https://doi.org/10.2217/nnm.16.22