Efficacy of Intrathecal MTX/Ara-C Combined with Systemic Chemotherapy in a Gastric Cancer Patient with Meningeal Carcinomatosis.

Authors :: Yamasaki T
Fukui H
Sei H
Hara K
Eda H
Kondo T
Toyoshima F
Kono T
Tozawa K
Ikehara H
Tomita T
Oshima T
Watari J
Miwa H
Source :: Internal medicine (Tokyo, Japan) [Intern Med] 2016; Vol. 55 (6), pp. 609-11. Date of Electronic Publication: 2016 Mar 15.
Publication Year :: 2016
Abstract: A 35-year-old man was diagnosed to have gastric cancer by endoscopic and histological examinations. Staging laparoscopy detected peritoneal metastasis. Systemic chemotherapy was started, but the patient complained of severe headache. Subsequently, a lumbar puncture demonstrated adenocarcinoma cells in the spinal fluid, suggesting the occurrence of meningeal carcinomatosis (MC) from gastric cancer. MC occurs only rarely in patients with gastric cancer, but the prognosis is invariably poor. However, this patient nevertheless survived for 12 months after receiving intrathecal MTX/Ara-C together with systemic chemotherapy. Therefore, the early detection of meningeal irritation sign and intrathecal chemotherapy might greatly improve the prognosis of gastric cancer patients with MC.

Subjects :: Adult
Cytarabine administration & dosage
Fatal Outcome
Headache etiology
Humans
Injections, Spinal
Male
Meningeal Carcinomatosis diagnosis
Meningeal Carcinomatosis pathology
Methotrexate administration & dosage
Prognosis
Spinal Puncture methods
Stomach Neoplasms complications
Stomach Neoplasms pathology
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Meningeal Carcinomatosis drug therapy
Stomach Neoplasms drug therapy

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