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Approaches to preventative and therapeutic HIV vaccines.
- Source :
-
Current opinion in virology [Curr Opin Virol] 2016 Apr; Vol. 17, pp. 104-109. Date of Electronic Publication: 2016 Mar 15. - Publication Year :
- 2016
-
Abstract
- Novel strategies are being researched to discover vaccines to prevent and treat HIV-1. Non-efficacious preventative vaccine approaches include bivalent recombinant gp120 alone, HIV gene insertion into an Adenovirus 5 (Ad5) virus vector and the DNA prime/Ad5 boost vaccine regimen. However, the ALVAC-HIV prime/AIDSVAX® B/E gp120 boost regimen showed 31.2% efficacy at 3.5 years, and is being investigated as clade C constructs with an additional boost. Likewise, although multiple therapeutic vaccines have failed in the past, in a non-placebo controlled trial, a Tat vaccine demonstrated immune cell restoration, reduction of immune activation, and reduced HIV-1 DNA viral load. Monoclonal antibodies for passive immunization or treatment show promise, with VRC01 entering advanced clinical trials.<br /> (Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- AIDS Vaccines administration & dosage
AIDS Vaccines genetics
AIDS Vaccines therapeutic use
Antibodies, Monoclonal administration & dosage
Antibodies, Monoclonal therapeutic use
Clinical Trials as Topic
Genetic Vectors
HIV genetics
HIV Envelope Protein gp120 genetics
HIV Envelope Protein gp120 immunology
HIV Infections virology
Humans
Immunization, Passive
Vaccination
Vaccines, DNA genetics
Vaccines, DNA therapeutic use
Viral Load
tat Gene Products, Human Immunodeficiency Virus immunology
AIDS Vaccines immunology
HIV immunology
HIV Infections prevention & control
HIV Infections therapy
Vaccines, DNA immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-6265
- Volume :
- 17
- Database :
- MEDLINE
- Journal :
- Current opinion in virology
- Publication Type :
- Academic Journal
- Accession number :
- 26985884
- Full Text :
- https://doi.org/10.1016/j.coviro.2016.02.010