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Apigenin ameliorates hypertension-induced cardiac hypertrophy and down-regulates cardiac hypoxia inducible factor-lα in rats.
- Source :
-
Food & function [Food Funct] 2016 Apr; Vol. 7 (4), pp. 1992-8. - Publication Year :
- 2016
-
Abstract
- Apigenin is a natural flavonoid compound that can inhibit hypoxia-inducible factor (HIF)-1α expression in cultured tumor cells under hypoxic conditions. Hypertension-induced cardiac hypertrophy is always accompanied by abnormal myocardial glucolipid metabolism due to an increase of HIF-1α. However, whether or not apigenin may ameliorate the cardiac hypertrophy and abnormal myocardial glucolipid metabolism remains unknown. This study aimed to examine the effects of apigenin. Rats with cardiac hypertrophy induced by renovascular hypertension were treated with apigenin 50-100 mg kg(-1) (the doses can be achieved by pharmacological or dietary supplementation for an adult person) by gavage for 4 weeks. The results showed that after treatment with apigenin, the blood pressure, heart weight, heart weight index, cardiomyocyte cross-sectional area, serum angiotensin II, and serum and myocardial free fatty acids were reduced. It is important to note that apigenin decreased the expression level of myocardial HIF-1α protein. Moreover, apigenin simultaneously increased the expression levels of myocardial peroxisome proliferator-activated receptor (PPAR) α, carnitine palmitoyltransferase (CPT)-1, and pyruvate dehydrogenase kinase (PDK)-4 proteins and decreased the expression levels of myocardial PPARγ, glycerol-3-phosphate acyltransferase genes (GPAT), and glucose transporter (GLUT)-4 proteins. These findings demonstrated that apigenin could improve hypertensive cardiac hypertrophy and abnormal myocardial glucolipid metabolism in rats, and its mechanisms might be associated with the down-regulation of myocardial HIF-1α expression and, subsequently increasing the expressions of myocardial PPARα and its target genes CPT-1 and PDK-4, and decreasing the expressions of myocardial PPARγ and its target genes GPAT and GLUT-4.
- Subjects :
- Animals
Cardiomegaly etiology
Cardiomegaly metabolism
Glucose Transporter Type 4 genetics
Glucose Transporter Type 4 metabolism
Humans
Hypoxia-Inducible Factor 1, alpha Subunit metabolism
Male
PPAR alpha genetics
PPAR alpha metabolism
Protein Kinases genetics
Protein Kinases metabolism
Rats
Rats, Sprague-Dawley
Apigenin administration & dosage
Cardiomegaly drug therapy
Cardiomegaly genetics
Down-Regulation drug effects
Hypertension complications
Hypoxia-Inducible Factor 1, alpha Subunit genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2042-650X
- Volume :
- 7
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Food & function
- Publication Type :
- Academic Journal
- Accession number :
- 26987380
- Full Text :
- https://doi.org/10.1039/c5fo01464f