Back to Search
Start Over
Microfluidic Manipulation of Core/Shell Nanoparticles for Oral Delivery of Chemotherapeutics: A New Treatment Approach for Colorectal Cancer.
- Source :
-
Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2016 Jun; Vol. 28 (21), pp. 4134-41. Date of Electronic Publication: 2016 Mar 22. - Publication Year :
- 2016
-
Abstract
- A microfluidics approach to synthesize core-shell nanocarriers with high pH tunability is described. The sacrificial shell protects the core layer with the drugs and prevents their release in the severe pH conditions of the gastrointestinal tract, while allowing for drug release in the proximity of a tumor. The proposed nanoparticulate drug-delivery system is designed for the oral administration of cancer therapeutics.<br /> (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Details
- Language :
- English
- ISSN :
- 1521-4095
- Volume :
- 28
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- Advanced materials (Deerfield Beach, Fla.)
- Publication Type :
- Academic Journal
- Accession number :
- 27001745
- Full Text :
- https://doi.org/10.1002/adma.201502697