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Outcome of tocilizumab treatment in refractory ocular inflammatory diseases.
- Source :
-
Acta ophthalmologica [Acta Ophthalmol] 2016 Sep; Vol. 94 (6), pp. e400-6. Date of Electronic Publication: 2016 Mar 24. - Publication Year :
- 2016
-
Abstract
- Purpose: To report the outcomes of tocilizumab treatment for refractory ocular inflammatory diseases.<br />Methods: A retrospective case series of 17 patients (28 eyes) diagnosed with recalcitrant ocular inflammatory diseases including uveitis (10 cases), scleritis (six cases) and orbital pseudotumour (one case), who received tocilizumab between April 2010 and March 2015. All patients were initiated with treatment of 4 mg/kg or 8 mg/kg tocilizumab. The primary outcome was absence of inflammation and achievement of steroid sparing at 6 and 9 months. Secondary outcomes were change in visual acuity and major adverse effects of tocilizumab causing discontinuation of the treatment.<br />Results: Mean age at initiation of tocilizumab was 41 ± 16 years. Prior to tocilizumab treatment, all patients underwent unsuccessful conventional immunosuppressive therapy while 94% of patients (16/17) failed treatment with various biological agents. After tocilizumab administration, control of inflammation and steroid sparing were achieved in 63% and 71% of uveitis patients at 6 and 9 months, while 50% of scleritis patients achieved the primary outcome at 6 and 9 months. Mean duration of tocilizumab therapy was 12.6 ± 10.0 (range, 2-35) months. Three of four patients who had a follow-up of at least 18 (range, 18-35) months experienced quiescent inflammation for up to 32 months of tocilizumab use until last visit. Four patients (24%) discontinued tocilizumab due to serious side effects including neutropenia, unacceptable dizziness and nausea, severe angioedema and severe abdominal pain.<br />Conclusion: Our series demonstrated moderate efficacy of tocilizumab in recalcitrant uveitis and scleritis. Serious adverse effects were not uncommon.<br /> (© 2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.)
- Subjects :
- Adolescent
Adult
Aged
Antibodies, Monoclonal, Humanized administration & dosage
Female
Fluorescein Angiography
Follow-Up Studies
Humans
Infusions, Intravenous
Interleukin-6 antagonists & inhibitors
Male
Middle Aged
Ophthalmoscopy
Orbital Pseudotumor diagnosis
Retrospective Studies
Scleritis diagnosis
Tomography, Optical Coherence
Treatment Outcome
Uveitis diagnosis
Visual Acuity
Antibodies, Monoclonal, Humanized therapeutic use
Orbital Pseudotumor drug therapy
Scleritis drug therapy
Uveitis drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1755-3768
- Volume :
- 94
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Acta ophthalmologica
- Publication Type :
- Academic Journal
- Accession number :
- 27010181
- Full Text :
- https://doi.org/10.1111/aos.13015