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High frequency oscillations can pinpoint seizures progressing to status epilepticus.
- Source :
-
Experimental neurology [Exp Neurol] 2016 Jun; Vol. 280, pp. 24-9. Date of Electronic Publication: 2016 Mar 24. - Publication Year :
- 2016
-
Abstract
- Status epilepticus (SE) is defined as a seizure lasting more than 5min or a period of recurrent seizures without recovery between them. SE is a serious emergency condition that requires immediate intervention; therefore, identifying SE electrophysiological markers may translate in prompt care to stop it. Here, we analyzed the EEG signals recorded from the CA3 region of the hippocampus and the entorhinal cortex in rats that responded to systemic administration of 4-aminopyridine (4AP) by generating either isolated seizures or seizures progressing to SE. We found that high frequency oscillations (HFOs) - which can be categorized as ripples (80-200Hz) and fast ripples (250-500Hz) - had different patterns of occurrence in the two groups (n=5 for each group). Specifically, fast ripples in CA3 and entorhinal cortex of the SE group occurred at higher rates than ripples, both during the ictal and post-ictal periods when compared to the HFOs recorded from the isolated seizure group. Our data reveal that different patterns of HFO occurrence can pinpoint seizures progressing to SE, thus suggesting the involvement of different neuronal networks at the termination of seizure discharges.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Subjects :
- 4-Aminopyridine toxicity
Animals
Brain Waves drug effects
Disease Models, Animal
Disease Progression
Electroencephalography
Hippocampus drug effects
Hippocampus physiopathology
Male
Periodicity
Potassium Channel Blockers toxicity
Rats
Rats, Sprague-Dawley
Status Epilepticus chemically induced
Brain Waves physiology
Seizures etiology
Status Epilepticus complications
Status Epilepticus pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2430
- Volume :
- 280
- Database :
- MEDLINE
- Journal :
- Experimental neurology
- Publication Type :
- Academic Journal
- Accession number :
- 27018321
- Full Text :
- https://doi.org/10.1016/j.expneurol.2016.03.021