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Renal oncocytosis: a clinicopathological and cytogenetic study of 42 tumours occurring in 11 patients.
- Source :
-
Pathology [Pathology] 2016 Jan; Vol. 48 (1), pp. 41-6. Date of Electronic Publication: 2015 Dec 18. - Publication Year :
- 2016
-
Abstract
- Renal oncocytosis is a rare pathological condition characterised by the presence of multiple oncocytic tumours with a spectrum of histological features ranging from renal oncocytoma, hybrid oncocytic tumour and rarely chromophobe renal cell carcinoma, sometimes overlapping. Here we retrospectively analysed histological, immunohistochemical (IHC), and cytogenetic features of 42 lesions in 11 patients with renal oncocytosis, not associated with Birt-Hogg-Dubé syndrome. The histology of all the lesions was blindly reviewed by three dedicated genitourinary pathologists. IHC for cytokeratin 7 (CK7) and fluorescence in situ hybridisation (FISH) for copy number variation of chromosomes 1, 6, 7 and 17 were performed in all 42 nodules. Among the 42 lesions 36 (85.7%) were histologically renal oncocytomas, two (4.76%) 'hybrid oncocytic tumours' (HOT), one (2.4%) clear cell renal cell carcinoma (ccRCC), one (2.4%) papillary renal cell carcinoma (pRCC), one typical angiomyolipoma (2.4%), and one mixed epithelial/stromal tumour of the kidney (2.4%). FISH analysis confirmed the histological diagnosis of all the lesions. We show that most patients with renal oncocytosis harbour benign or low malignant potential tumours that can be treated conservatively.<br /> (Copyright © 2015 The Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Adenoma, Oxyphilic genetics
Adult
Aged
Aged, 80 and over
Angiomyolipoma genetics
Carcinoma, Renal Cell genetics
DNA Copy Number Variations
Female
Humans
In Situ Hybridization, Fluorescence
Kidney pathology
Kidney Neoplasms genetics
Male
Middle Aged
Retrospective Studies
Adenoma, Oxyphilic pathology
Angiomyolipoma pathology
Carcinoma, Renal Cell pathology
Kidney Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1465-3931
- Volume :
- 48
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 27020208
- Full Text :
- https://doi.org/10.1016/j.pathol.2015.11.009