Back to Search
Start Over
A Direct Access to 7-Aminoindoles via Iridium-Catalyzed Mild C-H Amidation of N-Pivaloylindoles with Organic Azides.
- Source :
-
Organic letters [Org Lett] 2016 Apr 15; Vol. 18 (8), pp. 1892-5. Date of Electronic Publication: 2016 Mar 29. - Publication Year :
- 2016
-
Abstract
- Ir(III)-catalyzed regioselective direct C-7 amidation of indoles in reaction with organic azides has been developed. While its efficiency was varied by the choice of N-directing groups, N-pivaloylindoles were most effective in undergoing the desired amidation at room temperature over a broad range of substrates. The reaction was scalable, and deprotection of the chelation group was also facile.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 18
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 27023669
- Full Text :
- https://doi.org/10.1021/acs.orglett.6b00662