Back to Search
Start Over
Myosin II governs collective cell migration behaviour downstream of guidance receptor signalling.
- Source :
-
Journal of cell science [J Cell Sci] 2017 Jan 01; Vol. 130 (1), pp. 97-103. Date of Electronic Publication: 2016 Mar 31. - Publication Year :
- 2017
-
Abstract
- Border cell migration during Drosophila oogenesis is a potent model to study collective cell migration, a process involved in development and metastasis. Border cell clusters adopt two main types of behaviour during migration: linear and rotational. However, the molecular mechanism controlling the switch from one to the other is unknown. Here, we demonstrate that non-muscle Myosin II (NMII, also known as Spaghetti squash) activity controls the linear-to-rotational switch. Furthermore, we show that the regulation of NMII takes place downstream of guidance receptor signalling and is critical to ensure efficient collective migration. This study thus provides new insight into the molecular mechanism coordinating the different cell behaviours in a migrating cluster.<br /> (© 2017. Published by The Company of Biologists Ltd.)
Details
- Language :
- English
- ISSN :
- 1477-9137
- Volume :
- 130
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of cell science
- Publication Type :
- Academic Journal
- Accession number :
- 27034137
- Full Text :
- https://doi.org/10.1242/jcs.179952