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De-Risking Immunotherapy: Report of a Consensus Workshop of the Cancer Immunotherapy Consortium of the Cancer Research Institute.
- Source :
-
Cancer immunology research [Cancer Immunol Res] 2016 Apr; Vol. 4 (4), pp. 279-88. - Publication Year :
- 2016
-
Abstract
- With the recent FDA approvals of pembrolizumab and nivolumab, and a host of additional immunomodulatory agents entering clinical development each year, the field of cancer immunotherapy is changing rapidly. Strategies that can assist researchers in choosing the most promising drugs and drug combinations to move forward through clinical development are badly needed in order to reduce the likelihood of late-stage clinical trial failures. On October 5, 2014, the Cancer Immunotherapy Consortium of the Cancer Research Institute, a collaborative think tank composed of stakeholders from academia, industry, regulatory agencies, and patient interest groups, met to discuss strategies for de-risking immunotherapy development, with a focus on integrating preclinical and clinical studies, and conducting smarter early-phase trials, particularly for combination therapies. Several recommendations were made, including making better use of clinical data to inform preclinical research, obtaining adequate tissues for biomarker studies, and choosing appropriate clinical trial endpoints to identify promising drug candidates and combinations in nonrandomized early-phase trials.<br /> (©2016 American Association for Cancer Research.)
- Subjects :
- Animals
Antibodies, Monoclonal pharmacology
Antibodies, Monoclonal therapeutic use
Cancer Vaccines immunology
Cancer Vaccines therapeutic use
Clinical Trials, Phase I as Topic
Combined Modality Therapy
Disease Models, Animal
Drug Discovery
Drug Evaluation, Preclinical
Humans
Mice
Molecular Targeted Therapy
Immunotherapy adverse effects
Immunotherapy methods
Neoplasms immunology
Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2326-6074
- Volume :
- 4
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cancer immunology research
- Publication Type :
- Academic Journal
- Accession number :
- 27036972
- Full Text :
- https://doi.org/10.1158/2326-6066.CIR-16-0045