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Protocol of the Stroke in Korean Young Adults Study: A Multicenter Case-Control Study and Prospective Cohort Study.
- Source :
-
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2016 Jun; Vol. 25 (6), pp. 1503-8. Date of Electronic Publication: 2016 Mar 30. - Publication Year :
- 2016
-
Abstract
- Background: The incidence of ischemic stroke in young adults has been rising over recent decades, but there is still limited information on its risk factors, etiologies, and outcomes. Because these patients generally participate in social life, risk factors associated with lifestyle may have a great impact and need to be identified.<br />Methods: The SKY (Stroke in Korean Young Adults) study is a multicenter case-control study and a prospective cohort study in 8 tertiary medical centers in the Republic of Korea. The case subjects are patients aged 18-44 years with first-ever ischemic stroke occurring within 1 month of stroke onset, and the control subjects are age- and gender-matched community controls. Our aim is to include 470 cases and 470 controls. The main objective of our study is to determine the risk factors and the causes of ischemic stroke in Korean young adults. Both well-documented risk factors and little-known lifestyle-related risk factors such as lifestyle habits and psychological distress including job strain will be evaluated by comparing cases and controls using a structured questionnaire. Secondary objectives are to determine the risks of mortality, recurrent vascular events, and poststroke epilepsy in these patients. Conditional logistic regression analysis will be used to estimate odds ratios and 95% confidence intervals.<br />Conclusions: The SKY study is designed to obtain more insights into relatively little-known risk factors in young Korean adults with ischemic stroke. The results may also help identify the frequencies of uncommon etiologies and outcomes in these patients.<br /> (Copyright © 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Age of Onset
Brain Ischemia diagnostic imaging
Brain Ischemia mortality
Brain Ischemia therapy
Case-Control Studies
Female
Humans
Incidence
Life Style
Logistic Models
Male
Odds Ratio
Prognosis
Prospective Studies
Recurrence
Republic of Korea epidemiology
Research Design
Risk Assessment
Risk Factors
Stroke diagnostic imaging
Stroke mortality
Stroke therapy
Surveys and Questionnaires
Time Factors
Young Adult
Brain Ischemia epidemiology
Stroke epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8511
- Volume :
- 25
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
- Publication Type :
- Academic Journal
- Accession number :
- 27038977
- Full Text :
- https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.02.034