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Cytogenetic findings in patients diagnosed with breast cancer having undergone adjuvant chemotherapy regimens.
- Source :
-
Genetics and molecular research : GMR [Genet Mol Res] 2016 Mar 18; Vol. 15 (1). Date of Electronic Publication: 2016 Mar 18. - Publication Year :
- 2016
-
Abstract
- The aim of the present study was to investigate DNA damage in peripheral blood lymphocytes of breast cancer (BC) patients before and after administration of chemotherapy. We analyzed the frequency of sister chromatid exchange (SCE), occurrence of micronuclei (MN), and lymphocyte proliferation rate index (PRI) as cytogenetic markers in 28 female BC patients before and after chemotherapy, and in 20 age-matched healthy female volunteers. Prior to treatment, BC patients showed significantly increased background levels of SCE and MN, and lowered PRIs compared to healthy women. In comparison with pre-treatment levels, SCE and MN frequencies were significantly elevated and PRI reduced in blood samples collected after chemotherapy. Our findings indicate that SCE, MN, and PRI may serve as sensitive biomarkers for routine detection of the genetic abnormalities that may occur following administration of antineoplastic drugs in the clinical setting, as well as for the monitoring of high-risk patients receiving chemotherapy for BC.
- Subjects :
- Adult
Aged
Breast Neoplasms drug therapy
Breast Neoplasms genetics
Case-Control Studies
Cell Nucleus drug effects
Cell Nucleus pathology
DNA Damage
Female
Humans
Lymphocytes pathology
Middle Aged
Breast Neoplasms blood
Chemotherapy, Adjuvant adverse effects
Lymphocytes drug effects
Sister Chromatid Exchange drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1676-5680
- Volume :
- 15
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Genetics and molecular research : GMR
- Publication Type :
- Academic Journal
- Accession number :
- 27050960
- Full Text :
- https://doi.org/10.4238/gmr.15017699