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Long-term association between the dietary inflammatory index and cognitive functioning: findings from the SU.VI.MAX study.
- Source :
-
European journal of nutrition [Eur J Nutr] 2017 Jun; Vol. 56 (4), pp. 1647-1655. Date of Electronic Publication: 2016 Apr 07. - Publication Year :
- 2017
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Abstract
- Purpose: Inflammation is a ubiquitous underlying mechanism of the links between diet and cognitive functioning. No study has yet evaluated the overall inflammatory potential of the diet, using the dietary inflammatory index (DII), in relation to cognitive functioning. In a French cohort of middle-aged adults, we evaluated the association between the DII, assessed in midlife, and cognitive performance evaluated 13 years later.<br />Methods: The DII is a literature-derived dietary index developed to determine the inflammatory potential of diet. The DII was estimated at baseline (1994-1996) among 3080 subjects of the SU.VI.MAX (supplementation with antioxidant vitamins and minerals) cohort. Cognitive performance was assessed in 2007-2009 via a battery of standardized neuropsychological tests. Principal component analysis was performed to extract a summary score of cognitive performance. Multivariable-adjusted linear regression analyses were performed to provide regression coefficients and 95 % confidence intervals (95 % CI).<br />Results: In a multivariate model, a strong inverse association was observed between a higher DII (reflecting a more inflammatory diet) and overall cognitive functioning (mean difference Q4 vs. Q1 = -1.76; 95 % CI = -2.81, -0.72, P for trend =0.002). With regard to specific cognitive domains, similar associations were observed with scores reflecting verbal memory, but not executive functioning.<br />Conclusion: This study suggests that a pro-inflammatory diet at midlife might be associated with subsequent lower cognitive functioning. A diet exhibiting anti-inflammatory properties may help to maintain cognitive health during aging.<br />Clinical Trial Registration: Clinicaltrials.gov (number NCT00272428).
- Subjects :
- Adult
Aged
Antioxidants administration & dosage
Body Mass Index
Diet Records
Executive Function
Exercise
Female
Follow-Up Studies
Health Behavior
Humans
Inflammation prevention & control
Male
Memory
Micronutrients administration & dosage
Middle Aged
Neuropsychological Tests
Nutrition Assessment
Principal Component Analysis
Prospective Studies
Sensitivity and Specificity
Socioeconomic Factors
Aging
Cognition
Diet
Subjects
Details
- Language :
- English
- ISSN :
- 1436-6215
- Volume :
- 56
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- European journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 27055851
- Full Text :
- https://doi.org/10.1007/s00394-016-1211-3