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Birdshot Retinochoroidopathy: Differences in Clinical Characteristics between Patients with Early and Late Age of Onset.
- Source :
-
Ocular immunology and inflammation [Ocul Immunol Inflamm] 2017 Oct; Vol. 25 (5), pp. 589-595. Date of Electronic Publication: 2016 Apr 12. - Publication Year :
- 2017
-
Abstract
- Purpose: To describe differences in the clinical characteristics of birdshot retinochoroidopathy (BSRC) patients diagnosed early and later in life.<br />Methods: This is a retrospective cohort study. Age was primarily analyzed and 50 years of age at diagnosis was selected as a cut-off point.<br />Results: A total of 144 patients (288 eyes) were included; 68 with early-onset and 76 with late-onset BSRC. The younger group had a statistically significant higher rate of more severe iritis (p = 0.04); an average number of non-steroidal immunosuppressants and biologic agents (NSIB) (p = 0.04); and a prolonged time to initiation of NSIB (p = 0.01). There were only four patients (3%) who had >0.5+ cells in the anterior chamber.<br />Conclusions: Patients with early-onset BSRC carried a higher risk for anterior segment inflammation, had a more prolonged delay to initiation of treatment with NSIB, and required a greater number of NSIBs to achieve remission.
- Subjects :
- Adult
Age Distribution
Age of Onset
Aged
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Biological Factors therapeutic use
Birdshot Chorioretinopathy
Chorioretinitis drug therapy
Cyclosporine therapeutic use
Early Diagnosis
Female
Humans
Immunosuppressive Agents therapeutic use
Infliximab therapeutic use
Iritis drug therapy
Male
Middle Aged
Mycophenolic Acid therapeutic use
Retrospective Studies
Risk Factors
Visual Acuity
Young Adult
Chorioretinitis diagnosis
Iritis diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1744-5078
- Volume :
- 25
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Ocular immunology and inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 27070723
- Full Text :
- https://doi.org/10.3109/09273948.2016.1158278