Acylphenols and dimeric acylphenols from Myristica maxima Warb.

Authors :: Othman MA
Sivasothy Y
Looi CY
Ablat A
Mohamad J
Litaudon M
Awang K
Source :: Fitoterapia [Fitoterapia] 2016 Jun; Vol. 111, pp. 12-7. Date of Electronic Publication: 2016 Apr 10.
Publication Year :: 2016
Abstract: Giganteone E (1), a new dimeric acylphenol was isolated as a minor constituent from the bark of Myristica maxima Warb. The structure of 1 was established on the basis of 1D and 2D NMR techniques and LCMS-IT-TOF analysis. Malabaricones A-C (2-4), giganteones A and C (5 and 6), maingayones A and B (7 and 8), maingayic acid B (9) and β-sitosteryl oleate (10) were also characterized in this plant for the first time. Compound 10 was identified for the first time in the Myristicaceae. Compounds 2 and 5 were active against human prostate cancer cell-lines, thus making this the first report on the prostate cancer inhibiting potential of acylphenols and dimeric acylphenols. Compounds 1, 4, 5, 7 and 8 exhibited potent DPPH free radical scavenging activity. This is the first report on their free radical scavenging capacity.<br /> (Copyright © 2016. Published by Elsevier B.V.)