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Water-insoluble thin films from palmitoyl hyaluronan with tunable properties.
- Source :
-
Carbohydrate polymers [Carbohydr Polym] 2016 Jun 25; Vol. 144, pp. 68-75. Date of Electronic Publication: 2016 Feb 10. - Publication Year :
- 2016
-
Abstract
- Hyaluronan (HA) films exhibit properties suitable for various biomedical applications, but the solubility of HA limits their use in aqueous environments. Therefore, we developed water insoluble films based on palmitoyl esters of HA (pHA). Films were prepared from pHA samples with various degrees of substitution (DS) and molecular weights and their mechanical properties and swelling were characterized. Additionally, scanning electron microscopy and atomic force microscopy were used for visualization. Despite being prepared by solution casting, the films had a very smooth surface and were homogeneous in thickness. The film properties were in accordance with the polymer DS and molecular weight, enabling to tailor them for future applications by choosing a suitable pHA material. The behavior of the films toward cells was assessed in vitro. All films were non-cytotoxic and showed no adhesion of cells. These results show that the developed films are suitable candidates for various biomedical applications such as tissue engineering or wound healing.<br /> (Copyright © 2016 Elsevier Ltd. All rights reserved.)
- Subjects :
- Acylation
Animals
Cell Adhesion drug effects
Cell Line, Tumor
Flow Cytometry
Humans
Hyaluronic Acid analogs & derivatives
Hyaluronic Acid toxicity
Mice
Microscopy, Atomic Force
Microscopy, Electron, Scanning
Palmitates toxicity
Solubility
Swiss 3T3 Cells
Tensile Strength
Water chemistry
Hyaluronic Acid chemistry
Palmitates chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1344
- Volume :
- 144
- Database :
- MEDLINE
- Journal :
- Carbohydrate polymers
- Publication Type :
- Academic Journal
- Accession number :
- 27083794
- Full Text :
- https://doi.org/10.1016/j.carbpol.2016.02.027