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Prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma.
- Source :
-
Oncotarget [Oncotarget] 2016 Jun 07; Vol. 7 (23), pp. 35423-36. - Publication Year :
- 2016
-
Abstract
- The prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma (GC) has been widely reported and is still under debate. Here, we evaluated the prognostic significance of preoperative serum CA125, CA19-9 and CEA in patients with GC. 1692 patients with GC who underwent gastrectomy were divided into the training (from January 2005 to December 2011, n = 1024) and the validation (from January 2012 to December 2013, n = 668) cohorts. Positive groups of CA125 (> 13.72 U/ml), CA19-9 (> 23.36 U/ml) and CEA (> 4.28 ng/ml) were significantly associated with more advanced clinicopathological traits and worse outcomes than that of negative groups (all P < 0.01). In Cox regression analysis, tumor size (P < 0.001, P = 0.005), pTNM stage (P < 0.001, P < 0.001) and CA125 (P = 0.026, P = 0.005) were independent prognostic factors both in two cohorts. Nomograms of these two cohorts based on the number of positive serum tumor markers (NPTM) were more accurate in prognostic prediction than TNM stage alone. Our findings suggested that elevated preoperative serum CA125, CA19-9 and CEA were associated with more advanced clinicopathological traits and less favorable outcomes. In addition, CA125 as an independent prognostic factor should be further investigated. Nomogram based on NPTM could accurately predict the prognosis of GC patients.<br />Competing Interests: The authors indicate no potential conflicts of interest.
- Subjects :
- Adult
Aged
Biomarkers, Tumor blood
Carcinoma blood
Carcinoma mortality
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Prognosis
Proportional Hazards Models
Stomach Neoplasms blood
Stomach Neoplasms mortality
CA-125 Antigen blood
CA-19-9 Antigen blood
Carcinoembryonic Antigen blood
Carcinoma pathology
Membrane Proteins blood
Stomach Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1949-2553
- Volume :
- 7
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Oncotarget
- Publication Type :
- Academic Journal
- Accession number :
- 27097114
- Full Text :
- https://doi.org/10.18632/oncotarget.8770