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Impact of ACE2 gene polymorphism on antihypertensive efficacy of ACE inhibitors.
- Source :
-
Journal of human hypertension [J Hum Hypertens] 2016 Dec; Vol. 30 (12), pp. 766-771. Date of Electronic Publication: 2016 Apr 28. - Publication Year :
- 2016
-
Abstract
- Angiotensin-converting enzyme 2 (ACE2), a newly discovered member of renin-angiotensin-aldosterone system, counterbalances the actions of angiotensin-converting enzyme. The objective of our study was to assess the association between rs2106809 polymorphism in ACE2 gene and the blood pressure response to ACE inhibitors in untreated hypertensive patients. After a 2-week, double-blind placebo run-in period, either benazepril or imidapril was administered for 6 weeks to 497 patients with mild to moderate essential hypertension. The achieved changes in BP were analyzed for their association with genotypes at ACE2 gene loci. In female hypertensive patients, the genotype frequency of ACE2 rs2106809 was 36.7%, 45.2% and 18.1% for CC, CT and TT genotypes, respectively. After 6 weeks of treatment, the reductions in diastolic blood pressure were significantly greater in female patients carrying the CC or CT genotype compared with those carrying the TT genotype (9.62±6.83 or 10.2±7.2 versus 6.81±6.31 mm Hg, respectively; P=0.045, analysis of variance (ANOVA)). Moreover, the reductions in mean arterial pressure were significantly greater in female patients carrying the CC or CT genotype compared with those carrying the TT genotype (12.1±7.5 or 12.0±7.9 versus 8.38±6.83 mm Hg, respectively; P=0.035, ANOVA). In male hypertensive patients, the genotype frequency of ACE2 rs2106809 was 58.1% and 41.9% for C and T genotypes, respectively. However, no association could be observed in males. We conclude that ACE2 rs2106809 is an important predictive factor of the response to antihypertensive treatment with ACE inhibitors in Chinese female hypertensive patients.
- Subjects :
- Adult
Aged
Angiotensin-Converting Enzyme 2
Asian People genetics
China epidemiology
Double-Blind Method
Gene Frequency
Heterozygote
Homozygote
Humans
Hypertension enzymology
Hypertension genetics
Hypertension physiopathology
Middle Aged
Pharmacogenetics
Phenotype
Precision Medicine
Prospective Studies
Sex Factors
Time Factors
Treatment Outcome
Angiotensin-Converting Enzyme Inhibitors therapeutic use
Antihypertensive Agents therapeutic use
Arterial Pressure drug effects
Benzazepines therapeutic use
Hypertension drug therapy
Imidazolidines therapeutic use
Peptidyl-Dipeptidase A genetics
Pharmacogenomic Variants
Polymorphism, Single Nucleotide
Renin-Angiotensin System drug effects
Renin-Angiotensin System genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1476-5527
- Volume :
- 30
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of human hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 27121444
- Full Text :
- https://doi.org/10.1038/jhh.2016.24