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Prognostic performance of pre-treatment NLR and PLR in patients suffering from osteosarcoma.
- Source :
-
World journal of surgical oncology [World J Surg Oncol] 2016 Apr 29; Vol. 14, pp. 127. Date of Electronic Publication: 2016 Apr 29. - Publication Year :
- 2016
-
Abstract
- Background: Inflammatory response markers have been proposed to predict the clinical outcomes in various cancers. The aim of this study was to explore the influence of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) on the prognosis of osteosarcoma.<br />Methods: Three hundred fifty-nine patients who underwent curative surgery for osteosarcoma were enrolled from 2005 to 2010. NLR and PLR were calculated from peripheral blood cell counts taken at pre-treatment. Optimal cutoff values of NLR and PLR were determined on the basis of receiver operating characteristic curve analysis. A predictive model was established to predict the clinical outcome for overall survival, and the predictive accuracy of this model was determined by concordance index (c-index).<br />Results: Our results showed that advanced stage and metastasis at diagnosis were significantly associated with the high NLR and PLR groups. NLR was an independent prognostic indicator for overall survival (HR = 1.80, 95% CI = 1.35-2.41, P < 0.001) and progression-free survival (HR = 1.65, 95% CI = 1.26-2.15, P < 0.001), except for PLR. The nomogram could perform well in the prediction of overall survival in patients with osteosarcoma (c-index 0.829).<br />Conclusions: Our results suggest that both NLR and PLR can reflect clinical prognosis. NLR is more predictive of overall survival and progression-free survival than PLR.
- Subjects :
- Adenocarcinoma surgery
Adult
Aged
Bone Neoplasms surgery
Female
Follow-Up Studies
Humans
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Staging
Osteosarcoma surgery
Preoperative Care
Prognosis
Retrospective Studies
Survival Rate
Young Adult
Adenocarcinoma secondary
Biomarkers, Tumor analysis
Blood Platelets pathology
Bone Neoplasms pathology
Lymphocytes pathology
Neutrophils pathology
Osteosarcoma pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1477-7819
- Volume :
- 14
- Database :
- MEDLINE
- Journal :
- World journal of surgical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 27125872
- Full Text :
- https://doi.org/10.1186/s12957-016-0889-2