Back to Search
Start Over
Prevention and management of treatment failure to new oral hepatitis C drugs.
- Source :
-
Expert opinion on pharmacotherapy [Expert Opin Pharmacother] 2016 Jun; Vol. 17 (9), pp. 1215-23. Date of Electronic Publication: 2016 May 09. - Publication Year :
- 2016
-
Abstract
- Introduction: Chronic hepatitis C virus (HCV) infection has become a curable disease. Sustained virologic response rates above 90% have been achieved with recommended direct-acting antiviral (DAA) combinations in most registration trials. However, outcomes in real-world patients are lower. In patients experiencing DAA failure, resistance-associated variants (RAVs) are almost universally selected. At this time it is unclear when and how to re-treat hepatitis C in patients with prior DAA failure.<br />Areas Covered: The rate of DAA failure and predictors of lack of treatment response using distinct DAA combinations are analyzed. We discuss the management of HCV treatment failure and the impact of RAVs on re-treatment strategies.<br />Expert Opinion: Failure to DAA combinations occurs more often in chronic hepatitis C patients with baseline predictors of poor response, such as those with RAVs, genotypes 3 or 1a, advanced liver cirrhosis, elevated serum HCV-RNA and perhaps HIV coinfection. Impaired antiviral efficacy is more frequent when multiple factors are present. On-treatment predictors of DAA failure are poor drug adherence and development of side effects. Extending the length of therapy, adding ribavirin and/or using DAA from other drug families may allow successful re-treatment of most prior DAA failures.
- Subjects :
- Administration, Oral
Coinfection
Drug Resistance, Viral drug effects
Drug Therapy, Combination methods
Hepacivirus drug effects
Hepatitis C, Chronic diagnosis
Humans
Liver Cirrhosis drug therapy
Prognosis
Treatment Failure
Antiviral Agents administration & dosage
Hepatitis C drug therapy
Hepatitis C, Chronic drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1744-7666
- Volume :
- 17
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Expert opinion on pharmacotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 27149603
- Full Text :
- https://doi.org/10.1080/14656566.2016.1182156