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Inflammation-based prognostic system predicts postoperative survival of esophageal carcinoma patients with normal preoperative serum carcinoembryonic antigen and squamous cell carcinoma antigen levels.
- Source :
-
World journal of surgical oncology [World J Surg Oncol] 2016 May 05; Vol. 14, pp. 141. Date of Electronic Publication: 2016 May 05. - Publication Year :
- 2016
-
Abstract
- Background: The Glasgow Prognostic Score (GPS) is an established inflammation-based system that is used to predict the prognosis for several types of malignancies. In this retrospective study, we assessed the postoperative survival of 725 patients with non-metastatic esophageal squamous cell carcinoma who had normal preoperative serum tumor marker levels according to the GPS.<br />Methods: Among 1394 patients who underwent esophagectomy between August 2006 and December 2010, 725 with normal preoperative serum levels of carcinoembryonic antigen (CEA) and squamous cell carcinoma antigen (SCC-Ag) were enrolled. All demographic, pathologic, and survival data were analyzed retrospectively. Uni- and multivariate analyses were performed to evaluate the relationship with overall survival. The Kaplan-Meier analysis and log-rank tests were used to compare the survival curves between patients with GPS 0 (group A) and 1 or 2 (group B).<br />Results: Patients in group A exhibited significantly better 3- and 5-year cancer-specific survival (CSS) rates (0.780 and 0.759, respectively) than those in group B (0.624 and 0.605, respectively). Multivariate Cox regression analysis revealed that age, tumor length, pathological tumor-node-metastasis (pTNM) stage, venous invasion, lymph node metastasis, serum albumin and C-reactive protein levels, and GPS were associated with postoperative survival of these patients. Further multivariate analysis confirmed that GPS was an independent prognostic factor. The Kaplan-Meier analysis and log-rank tests demonstrated a significant difference in CSS between groups A and B (Pā=ā0.001).<br />Conclusions: GPS may be a valuable prognostic indicator for esophageal cancer patients with normal preoperative CEA and SCC-Ag serum levels.
- Subjects :
- Adult
Aged
Aged, 80 and over
Biomarkers, Tumor blood
C-Reactive Protein analysis
Carcinoma, Squamous Cell surgery
Esophageal Neoplasms surgery
Female
Follow-Up Studies
Humans
Inflammation pathology
Male
Middle Aged
Neoplasm Staging
Postoperative Period
Prognosis
Retrospective Studies
Severity of Illness Index
Survival Rate
Antigens, Neoplasm blood
Carcinoembryonic Antigen blood
Carcinoma, Squamous Cell blood
Carcinoma, Squamous Cell mortality
Esophageal Neoplasms blood
Esophageal Neoplasms mortality
Esophagectomy mortality
Inflammation blood
Serpins blood
Subjects
Details
- Language :
- English
- ISSN :
- 1477-7819
- Volume :
- 14
- Database :
- MEDLINE
- Journal :
- World journal of surgical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 27151090
- Full Text :
- https://doi.org/10.1186/s12957-016-0878-5