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The Formation of Seven-Membered Heterocycles under Mild Pictet-Spengler Conditions: A Route to Pyrazolo[3,4]benzodiazepines.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2016 Jun 03; Vol. 81 (11), pp. 4883-9. Date of Electronic Publication: 2016 May 13. - Publication Year :
- 2016
-
Abstract
- Reported is a method for the synthesis of seven-membered heterocycles via a Pictet-Spengler condensation reaction under very mild conditions. High substrate scope allows for use of aldehydes using catalytic amounts of acetic acid yielding 39-90% and ketones using catalytic amounts of trifluoroacetic acid yielding 25-83%.
Details
- Language :
- English
- ISSN :
- 1520-6904
- Volume :
- 81
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 27159074
- Full Text :
- https://doi.org/10.1021/acs.joc.6b00710